Defense lawyers will likely attack the lab procedures and argue that the DNA's presence at the scene is unexplained, rather than directly disputing the match. They might suggest Koberger touched the sheath in a store, or that the DNA was transferred innocently. However, once arrested, direct DNA comparison would supersede any previous genetic genealogy or paternity findings, providing a definitive one-to-one match.

Impact: High. This highlights the critical battleground for the defense: not disproving the DNA match, but creating reasonable doubt about how it got there. The prosecution's case hinges on linking the DNA directly to the crime, not just the suspect's father.

In the source video, this keypoint occurs from 00:54:03 to 00:56:41.

Sources in support: Megyn Kelly (Host), CeCe Moore (Genetic Genealogist)